Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.91 |
| ▸ | KDR | P35968 | 12/20 | 0.91 |
| ▸ | FLT3 | P36888 | 8/20 | 0.91 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | TEK | Q02763 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | PRKACG | P22612 | 2/20 | 0.44 |
| ▸ | PRKACB | P22694 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18655373 | 0.95 | GSK3B (0.91) | GSK3BKDRFLT3QPCT | |
| SCHEMBL9956127 | 0.95 | KDR (1.00) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL9955798 | 0.91 | GSK3B (1.00) | GSK3BKDRFLT3QPCTFLT4 | |
| SCHEMBL18655378 | 0.89 | GSK3B (0.86) | GSK3BKDRFLT3QPCT | |
| SCHEMBL19070784 | 0.85 | GSK3B (0.81) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL22334761 | 0.85 | KDR (0.81) | GSK3BKDRFLT3FLT4TEK | |
| SCHEMBL18655374 | 0.83 | GSK3B (0.87) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL10069744 | 0.82 | GSK3B (1.00) | GSK3BKDRFLT3QPCTFLT4 | |
| SCHEMBL19090416 | 0.81 | GSK3B (0.82) | GSK3BKDRFLT3QPCTFLT4 | |
| SCHEMBL18655372 | 0.81 | GSK3B (0.80) | GSK3BKDRFLT3QPCTFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655359-B1 | CONJUGATED 3-(INDOLYL)- AND 3-(AZAINDOLYL)-4-ARYLMALEIMIDE COMPOUNDS AND THEIR USE IN TUMOR TREATMENT | Johannes-Gutenberg-Universität Mainz (DE) | 2017-03-22 | — | — | EP | disclosed |