Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.80 |
| ▸ | KDR | P35968 | 11/20 | 0.66 |
| ▸ | FLT3 | P36888 | 8/20 | 0.66 |
| ▸ | QPCT | Q16769 | 1/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954914 | 0.95 | GSK3B (0.87) | GSK3BKDRFLT3QPCTCAMK2D | |
| SCHEMBL10069744 | 0.89 | GSK3B (1.00) | GSK3BKDRFLT3QPCTCAMK2D | |
| SCHEMBL18655375 | 0.88 | GSK3B (0.79) | GSK3BKDRFLT3QPCTCAMK2D | |
| SCHEMBL18655336 | 0.84 | GSK3B (0.86) | GSK3BKDRFLT3QPCTCAMK2D | |
| SCHEMBL18655373 | 0.83 | GSK3B (0.91) | GSK3BKDRFLT3QPCTCAMK2D | |
| SCHEMBL8540158 | 0.82 | PIM1 (0.65) | GSK3BCAMK2D | |
| SCHEMBL10070111 | 0.82 | GSK3B (0.68) | GSK3BKDRFLT3QPCTCAMK2D | |
| SCHEMBL18628480 | 0.82 | GSK3B (0.68) | GSK3BKDRFLT3QPCTCAMK2D | |
| SCHEMBL18655377 | 0.81 | GSK3B (0.91) | GSK3BKDRFLT3QPCTPLK4 | |
| SCHEMBL18655354 | 0.81 | GSK3B (0.61) | GSK3BKDRFLT3QPCTCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655359-B1 | CONJUGATED 3-(INDOLYL)- AND 3-(AZAINDOLYL)-4-ARYLMALEIMIDE COMPOUNDS AND THEIR USE IN TUMOR TREATMENT | Johannes-Gutenberg-Universität Mainz (DE) | 2017-03-22 | — | — | EP | disclosed |