Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.60 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL994681 | 1.00 | USP30 (0.60) | USP30GPR119JAK2JAK1STS | |
| SCHEMBL31294280 | 0.85 | ALDH1A1 (0.46) | USP30 | |
| SCHEMBL3313427 | 0.85 | USP30 (0.63) | USP30JAK2JAK1GABRA5PARP1 | |
| SCHEMBL16078940 | 0.85 | USP30 (0.58) | USP30GPR119JAK2JAK1STS | |
| SCHEMBL3313424 | 0.85 | USP30 (0.63) | USP30JAK2JAK1GABRA5PARP1 | |
| SCHEMBL30165296 | 0.85 | USP30 (0.63) | USP30JAK2JAK1GABRA5PARP1 | |
| SCHEMBL1251145 | 0.85 | DPP7 (0.42) | USP30KDM4E | |
| SCHEMBL28740025 | 0.85 | DPP7 (0.42) | USP30KDM4E | |
| SCHEMBL28779687 | 0.84 | USP30 (0.62) | USP30GPR119JAK2JAK1STS | |
| SCHEMBL22222650 | 0.84 | USP30 (0.62) | USP30GPR119JAK2JAK1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020216766-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2020-10-29 | — | — | WO | disclosed |
| EP-2857401-B1 | NOVEL -LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME | MEIJI SEIKA PHARMA CO LTD (JP) | 2019-09-18 | — | — | EP | disclosed |
| WO-2017045510-A1 | Β-LACTAMASE INHIBITOR AND APPLICATION THEREOF | 山东轩竹医药科技有限公司 | 2017-03-23 | — | — | WO | disclosed |