SCHEMBL18656772

SCHEMBL18656772

c1csc(-c2cnc(-c3ncc(-c4nc5scnc5s4)s3)s2)n1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.33
ADORA1 P30542 3/20 0.33
CYP2A6 P11509 1/20 0.33
PDPK1 O15530 1/20 0.33
HSP90AA1 P07900 1/20 0.32
RAB9A P51151 1/20 0.30
RIPK2 O43353 1/20 0.30
ADORA3 P0DMS8 1/20 0.30
ADORA2B P29275 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2339701 0.79 PDPK1 (0.43) ADORA2AADORA1CYP2A6PDPK1HSP90AA1
SCHEMBL929807 0.79 PDPK1 (0.43) ADORA2AADORA1CYP2A6PDPK1HSP90AA1
SCHEMBL26745554 0.76
SCHEMBL26745877 0.67 KDM4E (0.30) RAB9A
SCHEMBL3788170 0.67 PDPK1 (0.69) CYP2A6PDPK1RAB9A
SCHEMBL13325267 0.66 PLA2G4A (0.32)
SCHEMBL28570271 0.65 PDPK1 (0.41) ADORA2AADORA1CYP2A6PDPK1HSP90AA1
SCHEMBL23197226 0.65 PIK3CD (0.49) RAB9A
SCHEMBL25165433 0.65 IKBKB (0.33) ADORA2AADORA1CYP2A6PDPK1HSP90AA1
SCHEMBL25165452 0.65 PDPK1 (0.34) ADORA2AADORA1CYP2A6PDPK1HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170084846-A1 Liquid Crystal Photoalignment Materials LOMOX LTD (GB) 2017-03-23 US disclosed