Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176117 | 0.81 | SIGMAR1 (0.63) | SIGMAR1POLBCYP1A2CYP2D6TMEM97 | |
| SCHEMBL24351544 | 0.75 | SIGMAR1 (0.70) | SIGMAR1POLBALDH1A1HRH3L3MBTL3 | |
| SCHEMBL21120837 | 0.72 | SIGMAR1 (0.56) | SIGMAR1POLBCYP1A2CYP2D6TMEM97 | |
| SCHEMBL20285955 | 0.72 | SIGMAR1 (0.56) | SIGMAR1POLBCYP1A2CYP2D6TMEM97 | |
| SCHEMBL422200 | 0.71 | SIGMAR1 (0.56) | SIGMAR1POLBHRH3L3MBTL3MEN1 | |
| SCHEMBL25042302 | 0.71 | SIGMAR1 (0.65) | SIGMAR1POLBHRH3L3MBTL3KMT2A | |
| SCHEMBL20329553 | 0.71 | SIGMAR1 (0.55) | SIGMAR1POLBCYP1A2CYP2D6TMEM97 | |
| SCHEMBL15265110 | 0.71 | SIGMAR1 (0.63) | SIGMAR1POLBCYP1A2CYP2D6TMEM97 | |
| SCHEMBL78043 | 0.71 | SIGMAR1 (0.79) | SIGMAR1POLBALDH1A1MEN1KMT2A | |
| SCHEMBL9539677 | 0.71 | SIGMAR1 (0.79) | SIGMAR1POLBALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939509-B2 | Partial and full agonists of A1 adenosine receptors | GILEAD SCIENCES, INC. (US) | 2011-05-10 | — | — | US | disclosed |