Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.79 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539677 | 1.00 | SIGMAR1 (0.79) | SIGMAR1POLBSLC6A3HTR1ADRD2 | |
| Ethylene SCHEMBL28207535 | 0.96 | SIGMAR1 (0.74) | SIGMAR1POLBSLC6A3HTR1ADRD2 | |
| Methylamine SCHEMBL28040222 | 0.94 | SIGMAR1 (0.72) | SIGMAR1POLBSLC6A3HTR1ADRD2 | |
| Isothiocyanate SCHEMBL2892892 | 0.90 | SIGMAR1 (0.66) | SIGMAR1POLBSLC6A3HTR1ADRD2 | |
| SCHEMBL21465700 | 0.89 | SIGMAR1 (0.65) | SIGMAR1POLBSLC6A3HTR1ADRD2 | |
| SCHEMBL1711070 | 0.89 | SIGMAR1 (1.00) | SIGMAR1POLBKMT2AHTTCCR3 | |
| SCHEMBL27701997 | 0.89 | SIGMAR1 (0.64) | SIGMAR1POLBSLC6A3HTR1ADRD2 | |
| Sulfurous Acid SCHEMBL27938413 | 0.88 | SIGMAR1 (0.64) | SIGMAR1POLBSLC6A3HTR1ADRD2 | |
| SCHEMBL4425957 | 0.87 | SIGMAR1 (0.90) | SIGMAR1POLBKMT2AMEN1HTT | |
| SCHEMBL13150782 | 0.85 | SLC6A3 (0.83) | SIGMAR1SLC6A3HTR1ADRD2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020229968-A1 | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS INC. (CA) | 2020-11-19 | — | — | WO | claimed |
| EP-2593425-B1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS INC (US) | 2018-10-17 | — | — | EP | claimed |
| US-20160264621-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS, INC (US) | 2016-09-15 | — | — | US | claimed |
| US-20130184222-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS, INC (US) | 2013-07-18 | — | — | US | claimed |
| EP-2593425-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | Agios Pharmaceuticals, Inc. (US) | 2013-05-22 | — | — | EP | claimed |
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | claimed |
| US-20090163704-A1 | Use of Acid Scavengers in Removal of Protons (Acidity) of the Reaction Mass During Chlorination of Sucrose-6-Acetate | V.B. MEDICARE PRIVATE LIMITED (IN) | 2009-06-25 | — | — | US | claimed |
| CN-101273050-A | Use of acid scavengers in removal of protons (acidity) of the reaction mass during chlorination of sucrose-6- acetate | PHARMED MEDICARE PVT LTD (IN) | 2008-09-24 | — | — | CN | claimed |
| WO-2007054971-A2 | USE OF ACID SCAVENGERS IN REMOVAL OF PROTONS (ACIDITY) OF THE REACTION MASS DURING CHLORINATION OF SUCROSE-6- ACETATE | PHARMED MEDICARE PVT. LTD. (IN) | 2007-05-18 | — | — | WO | claimed |
| US-20040024000-A1 | Dihydropyrimidine derivatives as cysteine protease inhibitors | NAEJA PHARMACEUTICAL INC. (CA) | 2004-02-05 | — | — | US | claimed |
| EP-1326848-A1 | DIHYDROPYRIMIDINE DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS | Naeja Pharmaceutical Inc. (CA) | 2003-07-16 | — | — | EP | claimed |
| WO-2002032879-A1 | DIHYDROPYRIMIDINE DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS | NAEJA PHARMACEUTICAL INC. (CA) | 2002-04-25 | — | — | WO | claimed |
| CN-116444380-B | Method for realizing amino derivative alkylation by utilizing micro-flow field technology | 南京工业大学 | 2024-09-17 | — | — | CN | disclosed |
| US-11857746-B2 | Wound cleansing apparatus in-situ | SMITH & NEPHEW PLC (GB) | 2024-01-02 | — | — | US | disclosed |
| CN-114031477-B | Method for reducing amide compounds into amine compounds by cobalt catalysis | 浙江工业大学 | 2023-12-05 | — | — | CN | disclosed |
| US-20230346753-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | VALO HEALTH, INC. | 2023-11-02 | — | — | US | disclosed |
| WO-1995014690-A1 | MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-01 | — | — | WO | disclosed |
| US-4666461-A | Fuel treatment compositions | THE LUBRIZOL CORPORATION (US) | 1987-05-19 | — | — | US | disclosed |
| EP-0085510-B1 | COMPOSITIONS FOR USE IN ALCOHOL AND ALCOHOL CONTAINING FUELS | The Lubrizol Corporation (US) | 1986-04-16 | — | — | EP | disclosed |
| EP-0085510-A2 | Compositions for use in alcohol and alcohol containing fuels | The Lubrizol Corporation (US) | 1983-08-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130184222-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | IDH1, IDH3B, IDH3A | SIGMAR1 4776/4885POLB 118/4885SLC6A3 4516/4885 |
| US-20040024000-A1 | Dihydropyrimidine derivatives as cysteine protease inhibitors | DPEP1, DNPEP, PEPD | SIGMAR1 4388/4885POLB 3661/4885SLC6A3 2442/4885 |
| US-20160264621-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | IDH1, IDH3B, IDH3A | SIGMAR1 4776/4885POLB 118/4885SLC6A3 4516/4885 |
| US-20230346753-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NQO1 | SIGMAR1 2940/4885POLB 2930/4885SLC6A3 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.