Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.75 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | LYPLA1 | O75608 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25692822 | 0.83 | ALDH1A1 (1.00) | ACHEALDH1A1POLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL18658202 | 0.81 | DCUN1D1 (0.71) | ACHEALDH1A1POLBKDM4EKMT2A | |
| SCHEMBL2349204 | 0.79 | ALDH1A1 (0.67) | ALDH1A1POLBL3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL30020658 | 0.79 | ALDH1A1 (0.68) | ACHEALDH1A1POLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL15264440 | 0.77 | ALDH1A1 (0.66) | ACHEALDH1A1POLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL18657601 | 0.75 | SMN1; SMN2 (0.67) | ALDH1A1POLBL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL6865563 | 0.74 | FAAH (0.61) | ACHEALDH1A1POLBMAPTKDM4E | |
| SCHEMBL4006377 | 0.74 | ALDH1A1 (0.67) | ALDH1A1POLBL3MBTL1SMN1; SMN2CYP2C19 | |
| SCHEMBL31492222 | 0.74 | ALDH1A1 (0.67) | ALDH1A1POLBL3MBTL1SMN1; SMN2CYP2C19 | |
| SCHEMBL4004441 | 0.74 | ALDH1A1 (0.65) | ACHEALDH1A1POLBL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230021224-A1 | METHODS AND COMPOSITIONS OF INHIBITING DCN1-UBC12 INTERACTION | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2023-01-19 | — | — | US | disclosed |
| US-11116757-B2 | Methods and compositions of inhibiting DCN1-UBC12 interaction | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2021-09-14 | — | — | US | disclosed |
| US-20210069172-A1 | METHODS AND COMPOSITIONS OF INHIBITING DCN1-UBC12 INTERACTION | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2021-03-11 | — | — | US | disclosed |
| WO-2017049295-A1 | METHODS AND COMPOSITIONS OF INHIBITING DCN1-UBC12 INTERACTION | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230021224-A1 | METHODS AND COMPOSITIONS OF INHIBITING DCN1-UBC12 INTERACTION | UBQLN1, CUL1, DCUN1D1 | ACHE 3169/4885ALDH1A1 1996/4885POLB 1579/4885 |
| US-11116757-B2 | Methods and compositions of inhibiting DCN1-UBC12 interaction | UBQLN1, CUL1, DCUN1D1 | ACHE 3169/4885ALDH1A1 1996/4885POLB 1579/4885 |
| US-20210069172-A1 | METHODS AND COMPOSITIONS OF INHIBITING DCN1-UBC12 INTERACTION | UBQLN1, CUL1, DCUN1D1 | ACHE 3169/4885ALDH1A1 1996/4885POLB 1579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.