Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187048 | 0.93 | CNR2 (0.37) | CNR2POLBBTKMAPTSMN1; SMN2 | |
| SCHEMBL185517 | 0.92 | OPRL1 (0.37) | CNR2BTKSMN1; SMN2BDKRB1PTGES | |
| SCHEMBL186119 | 0.91 | PTK2 (0.37) | CNR2POLBBTKPTK2TRPV1 | |
| SCHEMBL2808148 | 0.90 | BDKRB1 (0.40) | CNR2POLBMAPTBDKRB1PTK2 | |
| SCHEMBL186660 | 0.90 | CNR2 (0.36) | CNR2POLBBTKMAPTALDH1A1 | |
| SCHEMBL186053 | 0.90 | CNR2 (0.34) | CNR2POLBBDKRB1TRPV1 | |
| SCHEMBL14856646 | 0.90 | CNR2 (0.35) | CNR2ALDH1A1HTR2AHTR2CKDM4E | |
| SCHEMBL14856813 | 0.85 | CNR2 (0.33) | CNR2PTGESTRPV1 | |
| SCHEMBL185744 | 0.85 | OPRL1 (0.36) | CNR2BTKBDKRB1MAPK10TRPV1 | |
| SCHEMBL14856697 | 0.85 | OPRL1 (0.35) | CNR2BDKRB1MAPK10TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |