Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186119 | 0.93 | PTK2 (0.37) | CNR2PTK2POLBTRPV1BTK | |
| SCHEMBL186586 | 0.93 | CNR2 (0.36) | CNR2PTK2POLBTRPV1BTK | |
| SCHEMBL185483 | 0.92 | OPRL1 (0.38) | CNR2PTK2TRPV1BTKP2RX7 | |
| SCHEMBL186053 | 0.91 | CNR2 (0.34) | CNR2POLBTRPV1FAAHTP53 | |
| SCHEMBL186076 | 0.90 | CNR2 (0.37) | CNR2TRPV1ANO1P2RX7FAAH | |
| SCHEMBL14856574 | 0.90 | CNR2 (0.35) | CNR2TRPV1ANO1P2RX7FAAH | |
| SCHEMBL185703 | 0.89 | FAAH (0.37) | CNR2PTK2POLBTRPV1BTK | |
| SCHEMBL185729 | 0.89 | CNR2 (0.35) | CNR2POLBTRPV1ANO1P2RX7 | |
| SCHEMBL2809554 | 0.89 | CNR2 (0.40) | CNR2PTK2POLBANO1P2RX7 | |
| SCHEMBL14856813 | 0.86 | CNR2 (0.33) | CNR2TRPV1FAAHTP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |