Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.31 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | CDC25A | P30304 | 1/20 | 0.30 |
| ▸ | CDC25B | P30305 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18659044 | 0.82 | LRRK2 (0.37) | LRRK2GRIN1GRIN2BPIK3CAPIK3CD | |
| SCHEMBL26808288 | 0.82 | GRIN1 (0.38) | LRRK2GRIN1GRIN2BCCNCCDK8 | |
| SCHEMBL30154915 | 0.81 | LRRK2 (0.36) | LRRK2 | |
| SCHEMBL18658646 | 0.81 | F2 (0.43) | LRRK2GRIN1GRIN2BCCNCCDK8 | |
| SCHEMBL18658642 | 0.80 | CHUK (0.38) | LRRK2GRIN1GRIN2BCCNCCDK8 | |
| SCHEMBL18606528 | 0.80 | LRRK2 (0.36) | LRRK2GRIN1GRIN2BCCNCCDK8 | |
| SCHEMBL18659043 | 0.80 | GRIN1 (0.40) | LRRK2GRIN1GRIN2BPIK3CAPIK3CD | |
| SCHEMBL18606456 | 0.80 | LRRK2 (0.52) | LRRK2GRIN1GRIN2BIRAK4PIK3CA | |
| SCHEMBL30154553 | 0.78 | LRRK2 (0.53) | LRRK2GRIN1GRIN2BIRAK4 | |
| SCHEMBL18659045 | 0.78 | LRRK2 (0.38) | LRRK2GRIN1GRIN2BCDK8PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017046675-A1 | NOVEL IMIDAZO [4,5-C] QUINOLINE AND IMIDAZO [4,5-C][1,5] NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER INC. (US) | 2017-03-23 | — | — | WO | disclosed |