Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 3/20 | 0.39 |
| ▸ | CDK8 | P49336 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18658642 | 0.86 | CHUK (0.38) | METAP2METAP1GRIN1GRIN2BCCNC | |
| SCHEMBL18659043 | 0.83 | GRIN1 (0.40) | GRIN1GRIN2BLRRK2 | |
| SCHEMBL18658760 | 0.83 | F2 (0.46) | F2F10F7METAP2METAP1 | |
| SCHEMBL26808288 | 0.81 | GRIN1 (0.38) | GRIN1GRIN2BCCNCCDK8PDE5A | |
| SCHEMBL18606456 | 0.81 | LRRK2 (0.52) | GRIN1GRIN2BLRRK2ALOX15TSHR | |
| SCHEMBL18606528 | 0.81 | LRRK2 (0.36) | GRIN1GRIN2BCCNCCDK8PDE5A | |
| SCHEMBL23935100 | 0.81 | HPGDS (0.40) | F10GRIN1GRIN2BPDE5AMAPT | |
| SCHEMBL18658823 | 0.81 | PDE10A (0.41) | GRIN1GRIN2BCCNCCDK8MAPT | |
| SCHEMBL18658804 | 0.81 | LRRK2 (0.51) | GRIN1GRIN2BCCNCCDK8LRRK2 | |
| SCHEMBL18659045 | 0.80 | LRRK2 (0.38) | GRIN1GRIN2BCDK8LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017046675-A1 | NOVEL IMIDAZO [4,5-C] QUINOLINE AND IMIDAZO [4,5-C][1,5] NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER INC. (US) | 2017-03-23 | — | — | WO | disclosed |