Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMURF2 | Q9HAU4 | 1/20 | 0.51 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17261679 | 0.85 | SMURF1 (0.69) | SMURF2SMURF1ALPLSRD5A2DUSP3 | |
| SCHEMBL17261744 | 0.85 | SMURF1 (0.49) | SMURF2SMURF1ALPLSRD5A2DUSP3 | |
| SCHEMBL17265791 | 0.85 | RAB9A (0.40) | SMURF2SMURF1ALPLTP53SMN1; SMN2 | |
| SCHEMBL17265790 | 0.82 | SMURF2 (0.49) | SMURF2SMURF1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL17261779 | 0.82 | SMURF2 (0.46) | SMURF2SMURF1ALPLSRD5A2DUSP3 | |
| SCHEMBL17261723 | 0.82 | SMURF1 (0.46) | SMURF2SMURF1ALPLSRD5A2DUSP3 | |
| SCHEMBL17261653 | 0.81 | SMURF2 (0.60) | SMURF2SMURF1ALPLSRD5A2DUSP3 | |
| SCHEMBL17265793 | 0.81 | SMURF2 (0.78) | SMURF2SMURF1DUSP3PTPN1 | |
| SCHEMBL17261678 | 0.80 | SMURF2 (0.45) | SMURF2SMURF1DUSP3PTPN1KMT2A | |
| SCHEMBL1686351 | 0.78 | PTPN1 (0.51) | DUSP3PTPN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170088545-A1 | CARBOXAMIDE INHIBITORS | NOVARTIS AG (CH) | 2017-03-30 | — | — | US | disclosed |
| US-20170088545-A1 | CARBOXAMIDE INHIBITORS | NOVARTIS AG (CH) | 2017-03-30 | — | — | US | disclosed |
| US-20170088545-A1 | CARBOXAMIDE INHIBITORS | NOVARTIS AG (CH) | 2017-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088545-A1 | CARBOXAMIDE INHIBITORS | SMURF1, SMURF2, SMYD2 | SMURF2 2/4885SMURF1 1/4885ALPL 4728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.