Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.37 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL3253044 | 0.93 | PAOX (0.38) | LMNATHRBBLMKMT2ANPSR1 | |
| Acetic Acid SCHEMBL28413060 | 0.93 | PAOX (0.38) | LMNATHRBBLMKMT2ANPSR1 | |
| Acetic Acid SCHEMBL5065362 | 0.93 | PAOX (0.38) | LMNATHRBBLMKMT2ANPSR1 | |
| Acetic Acid SCHEMBL28413059 | 0.93 | PAOX (0.38) | LMNATHRBBLMKMT2ANPSR1 | |
| Urea SCHEMBL27918835 | 0.91 | PAOX (0.34) | LMNATHRBBLMKMT2ANPSR1 | |
| Acetone SCHEMBL2390270 | 0.91 | PAOX (0.39) | LMNATHRBBLMKMT2ANPSR1 | |
| Methyl Alcohol SCHEMBL17579960 | 0.88 | LMNA (0.38) | LMNANFKB1 | |
| SCHEMBL9491840 | 0.88 | LMNA (0.40) | LMNABLMKMT2ATSHRNFKB1 | |
| SCHEMBL15124 | 0.88 | LMNA (0.40) | LMNABLMKMT2ATSHRNFKB1 | |
| Acetic Acid SCHEMBL3255424 | 0.87 | PAOX (0.41) | LMNATHRBBLMKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200248054-A1 | POLYURETHANE ADHESIVE LAYERS FOR ELECTRO-OPTIC ASSEMBLIES | E INK CORPORATION | 2020-08-06 | — | — | US | disclosed |
| US-10662354-B2 | Polyurethane adhesive layers for electro-optic assemblies | E INK CORPORATION (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190106609-A1 | POLYURETHANE ADHESIVE LAYERS FOR ELECTRO-OPTIC ASSEMBLIES | E INK CORPORATION | 2019-04-11 | — | — | US | disclosed |
| US-10174232-B2 | Polyurethane adhesive layers for electro-optic assemblies | E INK CORPORATION (US) | 2019-01-08 | — | — | US | disclosed |
| US-20170088758-A1 | POLYURETHANE ADHESIVE LAYERS FOR ELECTRO-OPTIC ASSEMBLIES | E INK CORPORATION | 2017-03-30 | — | — | US | disclosed |