Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18664520 | 1.00 | PAOX (0.37) | PAOXMEN1MAPTKMT2AATM | |
| SCHEMBL21370393 | 0.94 | MEN1 (0.42) | PAOXMEN1MAPTKMT2AATM | |
| SCHEMBL14885197 | 0.92 | PAOX (0.39) | PAOXMEN1MAPTKMT2AATM | |
| SCHEMBL20781421 | 0.87 | MEN1 (0.46) | PAOXMEN1MAPTKMT2AATM | |
| SCHEMBL21712880 | 0.85 | MEN1 (0.47) | PAOXMEN1MAPTKMT2AATM | |
| SCHEMBL19068981 | 0.82 | EPHX1 (0.33) | MEN1MAPTKMT2AATML3MBTL1 | |
| SCHEMBL18125148 | 0.80 | PAOX (0.39) | PAOXMEN1MAPTKMT2AATM | |
| SCHEMBL23770097 | 0.79 | LMNA (0.41) | PAOXMEN1MAPTKMT2AATM | |
| SCHEMBL20289689 | 0.79 | TDP1 (0.44) | MEN1KMT2AALDH1A1 | |
| SCHEMBL24690197 | 0.79 | ZDHHC20 (0.50) | MEN1KMT2AEPHX1MAPK1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670205-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2017-06-06 | — | — | US | disclosed |
| WO-2017048727-A1 | MODULATORS OF TOLL-LIKE RECPTORS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. (US) | 2017-03-23 | — | — | WO | disclosed |