Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 7/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid Methyl Ester SCHEMBL27937879 | 0.92 | VEGFA (0.52) | VEGFAEGLN1SIGMAR1ALDH1A1LMNA | |
| Tert-Butyl Formate SCHEMBL28809471 | 0.89 | VEGFA (0.49) | VEGFAEGLN1SIGMAR1ALDH1A1LMNA | |
| Ethoxycarbonyl Group SCHEMBL27937850 | 0.89 | VEGFA (0.49) | VEGFAEGLN1KDM4EALDH1A1LMNA | |
| SCHEMBL12598836 | 0.88 | VEGFA (0.76) | VEGFAEGLN1SIGMAR1CYP2A13KDM4E | |
| SCHEMBL1867899 | 0.86 | VEGFA (0.59) | VEGFAEGLN1CYP2A13KDM4EALDH1A1 | |
| SCHEMBL1869387 | 0.86 | VEGFA (0.64) | VEGFAEGLN1SIGMAR1CYP2A13KDM4E | |
| SCHEMBL1868736 | 0.86 | VEGFA (0.64) | VEGFAEGLN1SIGMAR1CYP2A13KDM4E | |
| SCHEMBL1771037 | 0.84 | VEGFA (0.65) | VEGFAEGLN1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL24254260 | 0.83 | VEGFA (0.63) | VEGFAEGLN1ALDH1A1LMNAMEN1 | |
| SCHEMBL27937875 | 0.82 | ALDH1A1 (0.45) | VEGFAEGLN1SIGMAR1CYP2A13KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496236-A1 | PROLYL HYDROXYLASE INHIBITORS | Aerpio Therapeutics Inc. (US) | 2012-09-12 | — | — | EP | claimed |
| WO-2011057115-A1 | PROLYL HYDROXYLASE INHIBITORS | AKEBIA THERAPEUTICS INC. (US) | 2011-05-12 | — | — | WO | claimed |