Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.70 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532585 | 0.95 | ALDH1A1 (0.91) | ALDH1A1KCNK3KCNK9NPSR1PKM | |
| SCHEMBL5816312 | 0.92 | ALDH1A1 (0.85) | ALDH1A1KCNK3KCNK9NPSR1PKM | |
| SCHEMBL23070448 | 0.88 | ALDH1A1 (0.78) | ALDH1A1KCNK3KCNK9NPSR1LMNA | |
| SCHEMBL16670220 | 0.87 | ALDH1A1 (0.77) | ALDH1A1KCNK3KCNK9NPSR1LMNA | |
| SCHEMBL13370008 | 0.85 | ALDH1A1 (0.74) | ALDH1A1KCNK3KCNK9NPSR1LMNA | |
| SCHEMBL15576244 | 0.84 | ALDH1A1 (0.71) | ALDH1A1KCNK3KCNK9NPSR1LMNA | |
| SCHEMBL259424 | 0.83 | NPSR1 (0.97) | ALDH1A1KCNK3KCNK9NPSR1LMNA | |
| SCHEMBL13105757 | 0.83 | ALDH1A1 (0.71) | ALDH1A1KCNK3KCNK9NPSR1LMNA | |
| SCHEMBL8352882 | 0.83 | ALDH1A1 (0.71) | ALDH1A1PKMALOX15NPC1GAA | |
| SCHEMBL2892842 | 0.83 | ALDH1A1 (0.71) | ALDH1A1GAATP53USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10626081-B2 | Farnesoid X receptor agonists and uses thereof | METACRINE, INC. (US) | 2020-04-21 | — | — | US | disclosed |
| US-10626081-B2 | Farnesoid X receptor agonists and uses thereof | METACRINE, INC. (US) | 2020-04-21 | — | — | US | disclosed |
| US-20180244606-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. | 2018-08-30 | — | — | US | disclosed |
| WO-2017049172-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2017-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180244606-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | NR1H4, NR1H2, NR1H3 | ALDH1A1 2205/4885KCNK3 4334/4885KCNK9 4608/4885 |
| US-10626081-B2 | Farnesoid X receptor agonists and uses thereof | NR1H4, NR1H2, NR1H3 | ALDH1A1 2205/4885KCNK3 4334/4885KCNK9 4608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.