Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.91 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.63 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18664786 | 0.95 | ALDH1A1 (1.00) | ALDH1A1NPSR1GAAKCNK3KCNK9 | |
| SCHEMBL5816312 | 0.94 | ALDH1A1 (0.85) | ALDH1A1NPSR1GAAKCNK3KCNK9 | |
| SCHEMBL8352882 | 0.84 | ALDH1A1 (0.71) | ALDH1A1GAATP53USP2NPC1 | |
| SCHEMBL2892842 | 0.84 | ALDH1A1 (0.71) | ALDH1A1GAATP53USP2 | |
| SCHEMBL23070448 | 0.83 | ALDH1A1 (0.78) | ALDH1A1NPSR1GAAKCNK3KCNK9 | |
| SCHEMBL12764072 | 0.83 | NPSR1 (0.94) | ALDH1A1NPSR1GAAUSP2SMN1; SMN2 | |
| SCHEMBL16670220 | 0.82 | ALDH1A1 (0.77) | ALDH1A1NPSR1GAAKCNK3KCNK9 | |
| SCHEMBL13370008 | 0.81 | ALDH1A1 (0.74) | ALDH1A1NPSR1GAAKCNK3KCNK9 | |
| SCHEMBL12825257 | 0.81 | NPSR1 (0.65) | ALDH1A1NPSR1GAAKCNK3KCNK9 | |
| SCHEMBL20608480 | 0.81 | GAA (0.77) | ALDH1A1NPSR1GAAKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208846-B1 | [7-(3-Disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID CO (US) | 1993-11-18 | — | — | EP | disclosed |
| US-4654347-A | USEFUL AS ANXIOLYTIC AND ANTIEPILEPTIC AGENTS, SEDATIVE-HYPNOTIC AGENTS AND SKELETAL MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1987-03-31 | — | — | US | disclosed |
| EP-0208846-A1 | [7-(3-Disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1987-01-21 | — | — | EP | disclosed |
| US-4626538-A | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1986-12-02 | — | — | US | disclosed |