Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | USP14 | P54578 | 1/20 | 0.33 |
| ▸ | UCHL5 | Q9Y5K5 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22556714 | 0.79 | TSHR (0.47) | LMNAPOLBALDH1A1MAPTKMT2A | |
| SCHEMBL1865742 | 0.77 | SRD5A2 (0.41) | SRD5A2LMNAALDH1A1MAPTGAA | |
| SCHEMBL22556898 | 0.75 | MAPT (0.39) | SRD5A2LMNAALDH1A1MAPTGAA | |
| SCHEMBL1872138 | 0.74 | CASP3 (0.39) | SRD5A2LMNAALDH1A1MAPTGAA | |
| SCHEMBL1863164 | 0.72 | CASP3 (0.47) | SRD5A2LMNAPOLBALDH1A1MAPT | |
| SCHEMBL1862784 | 0.72 | ACHE (0.51) | LMNAALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL15537076 | 0.71 | SRD5A2 (0.51) | SRD5A2ALDH1A1MAPTKMT2A | |
| SCHEMBL1870246 | 0.70 | CASP3 (0.47) | SRD5A2LMNAALDH1A1MAPTGAA | |
| SCHEMBL16950618 | 0.70 | MEN1 (0.45) | LMNAPOLBALDH1A1MAPTNTSR1 | |
| SCHEMBL27140785 | 0.70 | MAPT (0.58) | LMNAPOLBALDH1A1MAPTNTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493855-A1 | (1,1, 1,3, 3, 3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL) PHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE FOR THE TREATMENT OF ATHEROSCLEROSIS | MSD Oss B.V. (NL) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051282-A1 | (1,1, 1,3, 3, 3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL) PHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE FOR THE TREATMENT OF ATHEROSCLEROSIS | N.V. ORGANON (NL) | 2011-05-05 | — | — | WO | disclosed |