Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.31 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144199 | 1.00 | POLRMT (0.33) | POLRMTPRMT5WDR77RIPK1TNK2 | |
| SCHEMBL25608082 | 0.87 | POLRMT (0.33) | POLRMT | |
| SCHEMBL20144211 | 0.86 | TMPRSS2 (0.44) | POLRMTPRMT5WDR77TNK2TMPRSS2 | |
| SCHEMBL24339519 | 0.83 | POLRMT (0.33) | POLRMTTMPRSS2 | |
| SCHEMBL15580646 | 0.82 | PRMT5 (0.34) | PRMT5WDR77TNK2TMPRSS2 | |
| SCHEMBL19223073 | 0.82 | POLRMT (0.41) | POLRMT | |
| SCHEMBL16519865 | 0.82 | POLRMT (0.38) | POLRMTPRMT5WDR77RIPK1TNK2 | |
| SCHEMBL23034475 | 0.82 | POLRMT (0.41) | POLRMT | |
| SCHEMBL23685890 | 0.81 | TNK2 (0.31) | POLRMTRIPK1TNK2 | |
| SCHEMBL15998195 | 0.80 | POLRMT (0.35) | POLRMTRIPK1TMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3785717-B1 | METHODS FOR TREATING CORONAVIRIDAE INFECTIONS | GILEAD SCIENCES INC (US) | 2022-01-05 | — | — | EP | disclosed |
| EP-3212175-B1 | METHODS FOR THE PREPARATION OF RIBOSIDES | GILEAD SCIENCES INC (US) | 2021-11-24 | — | — | EP | disclosed |
| EP-3785717-A1 | METHODS FOR TREATING CORONAVIRIDAE INFECTIONS | Gilead Sciences, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2017184668-A1 | METHODS FOR TREATING FLAVIVIRIDAE VIRUS INFECTIONS | GILEAD SCIENCES, INC. (US) | 2017-10-26 | — | — | WO | disclosed |
| WO-2017049060-A1 | METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS | GILEAD SCIENCES, INC. (US) | 2017-03-23 | — | — | WO | disclosed |