Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10174704 | 0.88 | RIPK1 (0.32) | — | |
| SCHEMBL20144211 | 0.85 | TMPRSS2 (0.44) | PRMT5WDR77TMPRSS2TNK2 | |
| SCHEMBL18214669 | 0.83 | TNK2 (0.32) | TMPRSS2TNK2 | |
| SCHEMBL18666902 | 0.82 | POLRMT (0.33) | PRMT5WDR77TMPRSS2TNK2 | |
| SCHEMBL20144199 | 0.82 | POLRMT (0.33) | PRMT5WDR77TMPRSS2TNK2 | |
| SCHEMBL10142507 | 0.81 | POLRMT (0.38) | TMPRSS2 | |
| SCHEMBL14681865 | 0.81 | TMPRSS2 (0.34) | PRMT5WDR77TMPRSS2 | |
| SCHEMBL10120471 | 0.80 | TMPRSS2 (0.42) | TMPRSS2 | |
| SCHEMBL17109563 | 0.80 | TMPRSS2 (0.42) | TMPRSS2 | |
| SCHEMBL19644929 | 0.80 | TMPRSS2 (0.42) | TMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576534-B1 | 1'-SUBSTITUTED-CARBA-NUCLEOSIDE PRODRUGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES INC (US) | 2014-03-19 | — | — | EP | disclosed |