Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MPI | P34949 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18641455 | 0.84 | POLB (0.56) | POLBALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL18641427 | 0.81 | POLB (0.56) | POLBALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL18667084 | 0.80 | KMT2A (0.47) | POLBALDH1A1KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL18641553 | 0.80 | POLB (0.58) | POLBALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL18456841 | 0.77 | POLB (0.66) | POLBALDH1A1LMNAHPGDKDM4E | |
| Hydrochloric Acid SCHEMBL28427846 | 0.75 | ALDH1A1 (0.50) | POLBALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL8221788 | 0.75 | POLB (0.68) | POLBALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL30922228 | 0.75 | ALDH1A1 (0.53) | POLBALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL18641533 | 0.75 | POLB (0.49) | POLBALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL28228758 | 0.72 | POLB (0.59) | POLBALDH1A1LMNAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017048950-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2017-03-23 | — | — | WO | disclosed |