Sugi Predict

Sugi Predict / Compounds / SCHEMBL18667366

SCHEMBL18667366

SCHEMBL18667366

Nc1cc(C(=O)O)c(C(F)(F)F)cc1Sc1ccccc1C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.58
▸ ALDH1A1 P00352 2/20 0.58
▸ TDP1 Q9NUW8 2/20 0.58
▸ LMNA P02545 2/20 0.48
▸ MAPT P10636 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ POLB P06746 2/20 0.44
▸ PKM P14618 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ RXFP1 Q9HBX9 1/20 0.43
▸ HPGD P15428 1/20 0.41
▸ HSD17B10 Q99714 1/20 0.41
▸ IDO1 P14902 1/20 0.41
▸ CFTR P13569 1/20 0.40
▸ CA12 O43570 1/20 0.40
▸ CA1 P00915 1/20 0.40
▸ CA2 P00918 1/20 0.40
▸ CA4 P22748 1/20 0.40
▸ CA7 P43166 1/20 0.40
▸ CA9 Q16790 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21940429 0.89 ALDH1A1 (0.50) KDM4EALDH1A1TDP1LMNAMAPT
SCHEMBL18641497 0.82 CFTR (0.47) KDM4EALDH1A1TDP1LMNAMAPT
SCHEMBL17080243 0.81 KDM4E (0.62) KDM4EALDH1A1TDP1LMNAMAPT
SCHEMBL8531860 0.81 KDM4E (0.55) KDM4EALDH1A1TDP1LMNAMAPT
SCHEMBL7821948 0.81 KDM4E (0.66) KDM4EALDH1A1TDP1LMNAMAPT
SCHEMBL8531244 0.81 POLB (0.53) KDM4EALDH1A1TDP1LMNAMAPT
SCHEMBL18667430 0.78 ALDH1A1 (0.62) KDM4EALDH1A1TDP1LMNAMAPT
SCHEMBL17080173 0.78 KDM4E (0.67) KDM4EALDH1A1TDP1LMNAPOLB
SCHEMBL18667023 0.76 KDM4E (0.59) KDM4EALDH1A1TDP1LMNAPOLB
SCHEMBL2032649 0.75 KDM4E (0.71) KDM4EALDH1A1TDP1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025890-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES INC (US) 2024-01-25 — — US disclosed
US-20240025890-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES INC (US) 2024-01-25 — — US disclosed
US-20240025890-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES INC (US) 2024-01-25 — — US disclosed
US-11814376-B2 Hepatitis b core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2023-11-14 — — US disclosed
US-11814376-B2 Hepatitis b core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2023-11-14 — — US disclosed
US-11814376-B2 Hepatitis b core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2023-11-14 — — US disclosed
US-20230044112-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES, INC. (US) 2023-02-09 — — US disclosed
US-20230044112-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES, INC. (US) 2023-02-09 — — US disclosed
US-10968211-B2 Hepatitis B core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2021-04-06 — — US disclosed
US-10968211-B2 Hepatitis B core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2021-04-06 — — US disclosed
EP-3782626-A1 HEPATITIS B CORE PROTEIN MODULATORS Assembly Biosciences, Inc. (US) 2021-02-24 — — EP disclosed
EP-3782626-A1 HEPATITIS B CORE PROTEIN MODULATORS Assembly Biosciences, Inc. (US) 2021-02-24 — — EP disclosed
CN-112094264-A Hepatitis B core protein modulators 组装生物科学股份有限公司 2020-12-18 — — CN disclosed
CN-108347943-B Hepatitis B core protein modulators 组装生物科学股份有限公司 2020-07-10 — — CN disclosed
US-20200131168-A1 HEPATITIS B CORE PROTEIN MODULATORS INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2020-04-30 — — US disclosed
US-20200131168-A1 HEPATITIS B CORE PROTEIN MODULATORS INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2020-04-30 — — US disclosed
US-10377748-B2 Hepatitis B core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2019-08-13 — — US disclosed
US-10377748-B2 Hepatitis B core protein modulators ASSEMBLY BIOSCIENCES, INC. (US) 2019-08-13 — — US disclosed
US-20180258084-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES, INC. (US) 2018-09-13 — — US disclosed
WO-2017048950-A1 HEPATITIS B CORE PROTEIN MODULATORS ASSEMBLY BIOSCIENCES, INC. (US) 2017-03-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240025890-A1 HEPATITIS B CORE PROTEIN MODULATORS HAVCR2, FABP1, MAVS KDM4E 2170/4885ALDH1A1 4316/4885TDP1 4337/4885
US-20230044112-A1 HEPATITIS B CORE PROTEIN MODULATORS HAVCR2, FABP1, MAVS KDM4E 2170/4885ALDH1A1 4316/4885TDP1 4337/4885
US-10377748-B2 Hepatitis B core protein modulators HAVCR2, FABP1, MAVS KDM4E 2170/4885ALDH1A1 4316/4885TDP1 4337/4885
US-10968211-B2 Hepatitis B core protein modulators HAVCR2, FABP1, MAVS KDM4E 2170/4885ALDH1A1 4316/4885TDP1 4337/4885
US-11814376-B2 Hepatitis b core protein modulators HAVCR2, FABP1, MAVS KDM4E 2170/4885ALDH1A1 4316/4885TDP1 4337/4885
US-20200131168-A1 HEPATITIS B CORE PROTEIN MODULATORS HAVCR2, FABP1, MAVS KDM4E 2170/4885ALDH1A1 4316/4885TDP1 4337/4885
US-20180258084-A1 HEPATITIS B CORE PROTEIN MODULATORS HAVCR2, FABP1, MAVS KDM4E 2170/4885ALDH1A1 4316/4885TDP1 4337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.