Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18667107 | 0.92 | ROCK2 (0.36) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18667628 | 0.87 | ROCK2 (0.34) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21250468 | 0.86 | ROCK2 (0.34) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19984576 | 0.84 | ROCK2 (0.38) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18667626 | 0.81 | HDAC1 (0.37) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21250432 | 0.81 | RXFP1 (0.45) | ROCK2ROCK1TP53MAPTMEN1 | |
| SCHEMBL18667142 | 0.81 | ROCK2 (0.35) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21250368 | 0.80 | ROCK2 (0.34) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18667750 | 0.79 | NAMPT (0.36) | TP53MAPTNAMPTPOLBRXFP1 | |
| SCHEMBL23018413 | 0.78 | KMT2A (0.45) | TP53MAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017048950-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2017-03-23 | — | — | WO | disclosed |