Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1876442 | 0.81 | PTGS1 (0.53) | RAB9ANPC1PTGS1PTGS2KDM4E | |
| SCHEMBL1876349 | 0.80 | PTGS1 (0.51) | RAB9ANPC1PTGS1PTGS2KDM4E | |
| SCHEMBL1871359 | 0.76 | PTGS1 (0.48) | RAB9ANPC1PTGS1PTGS2KDM4E | |
| SCHEMBL1382899 | 0.74 | MEN1 (0.67) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1870832 | 0.73 | TSHR (0.54) | RAB9ANPC1PTGS1PTGS2KDM4E | |
| SCHEMBL2468923 | 0.73 | RAB9A (1.00) | RAB9ANPC1PTGS1PTGS2KDM4E | |
| SCHEMBL1878184 | 0.72 | HSD17B10 (0.44) | RAB9ANPC1PTGS1PTGS2KDM4E | |
| SCHEMBL8892175 | 0.72 | MEN1 (0.52) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL1871212 | 0.71 | BCL2L1 (0.45) | RAB9ANPC1PTGS1PTGS2KDM4E | |
| SCHEMBL10536719 | 0.69 | TAAR1 (0.61) | KDM4ESMN1; SMN2POLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496574-A1 | IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION | Abbott Laboratories (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011053476-A1 | IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | WO | disclosed |