Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | APAF1 | O14727 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | BCHE | P06276 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.70 |
| ▸ | ACHE | P22303 | 1/20 | 0.70 |
| ▸ | CES1 | P23141 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17866111 | 0.87 | KMT2A (0.56) | ALDH1A1ALOX15HSD17B10APAF1TSHR | |
| SCHEMBL1837584 | 0.85 | ALOX15 (0.68) | ALDH1A1ALOX15HSD17B10APAF1TSHR | |
| SCHEMBL2040789 | 0.85 | CA12 (0.55) | ALDH1A1ALOX15HSD17B10APAF1TSHR | |
| SCHEMBL3029864 | 0.85 | KMT2A (0.59) | ALDH1A1ALOX15HSD17B10APAF1TSHR | |
| SCHEMBL10928006 | 0.85 | ALOX15 (0.56) | ALDH1A1ALOX15HSD17B10APAF1TSHR | |
| SCHEMBL5958272 | 0.85 | CASP3 (0.59) | ALDH1A1ALOX15HSD17B10APAF1TSHR | |
| SCHEMBL5115439 | 0.85 | CASP3 (0.55) | ALDH1A1ALOX15HSD17B10APAF1TSHR | |
| SCHEMBL2780391 | 0.84 | HDAC7 (0.60) | ALDH1A1ALOX15HSD17B10APAF1TSHR | |
| SCHEMBL18668986 | 0.84 | MAPT (0.73) | ALDH1A1ALOX15HSD17B10APAF1TSHR | |
| SCHEMBL5426477 | 0.83 | ALDH1A1 (1.00) | ALDH1A1ALOX15HSD17B10APAF1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |