Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 7/20 | 0.69 |
| ▸ | PARP1 | P09874 | 9/20 | 0.54 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.47 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22387755 | 0.82 | IP6K1 (1.00) | IP6K1PARP1IP6K3IP6K2DHFR | |
| SCHEMBL18669149 | 0.79 | QPCT (0.44) | IP6K1PARP1ABL1ALDH1A1 | |
| SCHEMBL14550820 | 0.77 | IP6K1 (0.77) | IP6K1PARP1IP6K3IP6K2DHFR | |
| SCHEMBL18687959 | 0.76 | JAK2 (0.47) | IP6K1PARP1JAK2CHEK1ALDH1A1 | |
| SCHEMBL17315551 | 0.76 | IP6K1 (0.64) | IP6K1PARP1IP6K3IP6K2DHFR | |
| SCHEMBL6886187 | 0.73 | PARP1 (0.63) | IP6K1PARP1IP6K3IP6K2PIM1 | |
| SCHEMBL18669065 | 0.72 | NPC1 (0.49) | ABL1ALDH1A1 | |
| SCHEMBL29784205 | 0.71 | PARP1 (1.00) | IP6K1PARP1IP6K3IP6K2PIM1 | |
| SCHEMBL2191006 | 0.71 | PARP1 (1.00) | IP6K1PARP1IP6K3IP6K2PIM1 | |
| SCHEMBL7804830 | 0.71 | DHFR (0.58) | IP6K1PARP1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |