Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | PIM1 | P11309 | 2/20 | 0.64 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | IP6K1 | Q92551 | 7/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.56 |
| ▸ | IP6K3 | Q96PC2 | 5/20 | 0.54 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29784205 | 1.00 | PARP1 (1.00) | PARP1ALDH1A1PIM1PIM3CHEK1 | |
| SCHEMBL29898482 | 0.85 | ALDH1A1 (1.00) | PARP1ALDH1A1PIM1PIM3CHEK1 | |
| SCHEMBL643424 | 0.85 | ALDH1A1 (1.00) | PARP1ALDH1A1PIM1PIM3CHEK1 | |
| SCHEMBL8622180 | 0.81 | ACVR1 (0.73) | PARP1PIM1PIM3CHEK1AKT1 | |
| SCHEMBL11877318 | 0.78 | PARP1 (0.61) | PARP1ALDH1A1PIM1PIM3CHEK1 | |
| SCHEMBL13718572 | 0.78 | PARP1 (0.63) | PARP1ALDH1A1PIM1PIM3CHEK1 | |
| SCHEMBL2081677 | 0.78 | PARP1 (1.00) | PARP1PIM1PIM3CHEK1AKT1 | |
| SCHEMBL2191067 | 0.78 | PARP1 (1.00) | PARP1ALDH1A1PIM1PIM3CHEK1 | |
| SCHEMBL216176 | 0.78 | PARP1 (1.00) | PARP1ALDH1A1PIM1PIM3CHEK1 | |
| SCHEMBL642178 | 0.78 | PARP1 (1.00) | PARP1PIM1PIM3CHEK1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240327382-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 | ALMAC DISCOVERY LIMITED (GB) | 2024-10-03 | — | — | US | disclosed |
| CN-117946012-A | Preparation method of nitrogen-containing heterocycle | 温州理工学院 | 2024-04-30 | — | — | CN | disclosed |
| EP-4073043-B1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY | CENTESSA PHARMACEUTICALS UK LTD (GB) | 2024-04-03 | — | — | EP | disclosed |
| CN-112105419-B | Condensed ring compound | 豪夫迈·罗氏有限公司 | 2024-03-29 | — | — | CN | disclosed |
| EP-4313295-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | Almac Discovery Limited (GB) | 2024-02-07 | — | — | EP | disclosed |
| CN-117157285-A | Pharmaceutical compounds as ubiquitin-specific protease 19 (USP 19) inhibitors | 阿尔麦克探索有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-116804001-A | Quinazolinone derivative containing pyridinium and preparation method and application thereof | 江苏海洋大学 | 2023-09-26 | — | — | CN | disclosed |
| CN-113637011-B | Myricetin derivative containing quinazoline-4 (3H) -ketone and preparation method and application thereof | 贵州大学 | 2023-03-31 | — | — | CN | disclosed |
| US-20230102488-A1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY | OXFORD FINANCE LLC | 2023-03-30 | — | — | US | disclosed |
| US-20230102488-A1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY | OXFORD FINANCE LLC | 2023-03-30 | — | — | US | disclosed |
| US-20090054646-A1 | Method for Production of Quinazolin 4-One Derivative | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1997812-A1 | METHOD FOR PRODUCTION OF QUINAZOLIN-4-ON DERIVATIVE | Mitsubishi Gas Chemical Company, Inc. (JP) | 2008-12-03 | — | — | EP | disclosed |
| US-7232903-B2 | Process for producing quinazolin-4-one and derivatives thereof | UBE INDUSTRIES, LTD. (JP) | 2007-06-19 | — | — | US | disclosed |
| US-20050124809-A1 | Process for producing quinazolin-4-one and derivatives thereof | UBE INDUSTRIES, LTD. (JP) | 2005-06-09 | — | — | US | disclosed |
| US-20050107409-A1 | Aromatic bicyclic compounds, preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-05-19 | — | — | US | disclosed |
| CN-1597671-A | Quinazoline deriative and preparation method and bioactivity | UNIV GUIZHOU (CN) | 2005-03-23 | — | — | CN | disclosed |
| EP-1466907-A1 | PROCESS FOR PRODUCING QUINAZOLIN-4-ONE AND DERIVATIVE THEREOF | Ube Industries, Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-0023594-B1 | TRANS-QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, INTERMEDIATES AND MEDICAMENTS CONTAINING THESE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-05-16 | — | — | EP | disclosed |
| US-4281127-A | USEFUL AS ANTIALLERGENS | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
| EP-0023594-A1 | Trans-Quinazoline derivatives, processes for their preparation, intermediates and medicaments containing these derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-02-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240327382-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 | USP19, USP18, UBE2I | PARP1 1106/4885ALDH1A1 792/4885PIM1 2887/4885 |
| US-20050124809-A1 | Process for producing quinazolin-4-one and derivatives thereof | ASNS, NQO2, KYNU | PARP1 1136/4885ALDH1A1 2564/4885PIM1 2218/4885 |
| US-20050107409-A1 | Aromatic bicyclic compounds, preparation thereof and their use as pharmaceutical compositions | F12, F2, F11 | PARP1 389/4885ALDH1A1 1078/4885PIM1 3497/4885 |
| US-20090054646-A1 | Method for Production of Quinazolin 4-One Derivative | NQO2, ALDH7A1, ALAD | PARP1 2157/4885ALDH1A1 314/4885PIM1 4206/4885 |
| US-20230102488-A1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY | SERPINA2, SERPINB1, SERPINH1 | PARP1 1457/4885ALDH1A1 47/4885PIM1 3426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.