Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.51 |
| ▸ | BCL6 | P41182 | 3/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.47 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5639514 | 0.81 | JAK3 (0.60) | AHRBCL6KIF11PTK2JAK3 | |
| SCHEMBL18669036 | 0.80 | IDH1 (0.48) | KIF11IDH1MAOBKDM4EALDH1A1 | |
| SCHEMBL1946174 | 0.77 | AHR (0.53) | AHRBCL6KIF11PGRMAPT | |
| SCHEMBL27333540 | 0.77 | CRHBP (0.41) | AHRIDH1MAPTKDM4EALDH1A1 | |
| SCHEMBL13996622 | 0.77 | AHR (0.51) | AHRBCL6KIF11GRIA1CACNG8 | |
| SCHEMBL18669106 | 0.75 | PARP1 (0.59) | IDH1MAPTALDH1A1 | |
| SCHEMBL12874455 | 0.74 | KIF11 (0.51) | AHRBCL6KIF11SMYD3JAK3 | |
| SCHEMBL18168411 | 0.74 | IDH1 (0.83) | IDH1 | |
| SCHEMBL3132579 | 0.74 | GAA (0.53) | AHRPGRGRIA1CACNG8MAPT | |
| SCHEMBL18189570 | 0.73 | GRIA1 (0.73) | AHRPGRGRIA1CACNG8GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |