Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18669233 | 0.86 | CHRM5 (0.50) | MAPTTRAP1CHRM5CHRM3MEN1 | |
| SCHEMBL18669089 | 0.84 | KDM4E (0.67) | KDM4EMAPTMAPK1MEN1KMT2A | |
| SCHEMBL18669206 | 0.83 | CA1 (0.52) | MAPK1TRAP1CHRM5CHRM3MEN1 | |
| SCHEMBL18669181 | 0.81 | AHR (0.43) | KDM4EMAPTTRAP1CHRM5CHRM3 | |
| SCHEMBL18669061 | 0.77 | SMN1; SMN2 (0.46) | KDM4EMAPTMAPK1MEN1KMT2A | |
| SCHEMBL18668938 | 0.76 | MEN1 (0.43) | KDM4EMAPTMAPK1MEN1KMT2A | |
| SCHEMBL18668986 | 0.75 | MAPT (0.73) | KDM4EMAPTMAPK1MEN1KMT2A | |
| SCHEMBL18668947 | 0.74 | KDM4E (0.63) | KDM4EMAPTMAPK1MEN1KMT2A | |
| SCHEMBL18669001 | 0.71 | CA9 (0.55) | CHRM5CHRM3HPGD | |
| SCHEMBL18688197 | 0.70 | MAPT (0.76) | KDM4EMAPTMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |