Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 4/20 | 0.50 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18669196 | 0.86 | KDM4E (0.54) | CHRM5TRAP1CHRM3HSP90AA1HSP90B1 | |
| SCHEMBL18669001 | 0.84 | CA9 (0.55) | CHRM5CHRM3GRM5ADRA1DADRA1A | |
| SCHEMBL18669206 | 0.81 | CA1 (0.52) | CHRM5TRAP1CHRM3GRM5MEN1 | |
| SCHEMBL31255159 | 0.81 | GRM5 (0.46) | CHRM5CHRM3GRM5ADRA1DADRA1A | |
| SCHEMBL3729290 | 0.80 | GRM5 (0.54) | GRM5TYRHTTMEN1ALDH1A1 | |
| SCHEMBL17866111 | 0.79 | KMT2A (0.56) | ADRA1DADRA1AADRA1BHTTMEN1 | |
| SCHEMBL18669181 | 0.79 | AHR (0.43) | CHRM5TRAP1CHRM3GRM5ALDH1A1 | |
| SCHEMBL3729405 | 0.78 | TYR (0.49) | GRM5ADRA1DADRA1AADRA1BTYR | |
| SCHEMBL13077677 | 0.78 | RPS6KA2 (0.50) | TYRHTTMEN1ALDH1A1GAA | |
| SCHEMBL24827438 | 0.77 | KMT2A (0.58) | CHRM5CHRM3ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |