Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18669285 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RAB9ACYP2C19GRIN2D | |
| SCHEMBL18669297 | 0.93 | LMNA (0.39) | SMN1; SMN2NPC1RAB9ACYP2C19GRIN2D | |
| SCHEMBL18669294 | 0.93 | LMNA (0.39) | SMN1; SMN2NPC1RAB9ACYP2C19GRIN2D | |
| SCHEMBL18689001 | 0.86 | JAK2 (0.50) | SMN1; SMN2GAA | |
| SCHEMBL20515959 | 0.86 | JAK2 (0.50) | SMN1; SMN2GAA | |
| SCHEMBL2526379 | 0.83 | GRIN2D (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19GRIN2D | |
| SCHEMBL18426023 | 0.83 | GRIN2D (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19GRIN2D | |
| SCHEMBL2525766 | 0.83 | GRIN2D (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19GRIN2D | |
| SCHEMBL18688987 | 0.83 | NAAA (0.38) | NPC1RAB9ANAMPTAGTR2BCHE | |
| SCHEMBL20515963 | 0.80 | PRMT5 (0.49) | BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137541-B | Pyridone dicarboxamides for use as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2021-07-06 | — | — | CN | disclosed |
| EP-3353162-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2018-08-01 | — | — | EP | disclosed |
| WO-2017050714-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-30 | — | — | WO | disclosed |