Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 7/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 5/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18671891 | 1.00 | DNM1 (0.43) | DNM1LMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL4596073 | 0.90 | SMN1; SMN2 (0.36) | DNM1LMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL21940892 | 0.87 | DNM1 (0.50) | DNM1TSHRFDPSGGPS1AGTR1 | |
| SCHEMBL24916182 | 0.85 | DNM1 (0.48) | DNM1TSHRFDPSGGPS1AGTR1 | |
| SCHEMBL24309469 | 0.82 | DNM1 (0.56) | DNM1ALDH1A1TSHRFDPSGGPS1 | |
| SCHEMBL19226492 | 0.80 | DNM1 (0.43) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL21214490 | 0.80 | DNM1 (0.43) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL19788363 | 0.80 | DNM1 (0.54) | DNM1ALDH1A1TSHRFDPSGGPS1 | |
| SCHEMBL22951461 | 0.79 | DNM1 (0.44) | DNM1TSHRFDPSGGPS1 | |
| SCHEMBL22420015 | 0.79 | DNM1 (0.50) | DNM1ALDH1A1TSHRFDPSGGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884043-B2 | RORgammaT inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-02-06 | — | — | US | disclosed |
| US-9603838-B2 | RORgammaT inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-28 | — | — | US | disclosed |