Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 7/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 5/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18671880 | 1.00 | DNM1 (0.43) | DNM1LMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL4596073 | 0.90 | SMN1; SMN2 (0.36) | DNM1LMNAALDH1A1HSD17B10MEN1 | |
| SCHEMBL21940892 | 0.87 | DNM1 (0.50) | DNM1TSHRFDPSGGPS1AGTR1 | |
| SCHEMBL24916182 | 0.85 | DNM1 (0.48) | DNM1TSHRFDPSGGPS1AGTR1 | |
| SCHEMBL24309469 | 0.82 | DNM1 (0.56) | DNM1ALDH1A1TSHRFDPSGGPS1 | |
| SCHEMBL19226492 | 0.80 | DNM1 (0.43) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL21214490 | 0.80 | DNM1 (0.43) | DNM1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL19788363 | 0.80 | DNM1 (0.54) | DNM1ALDH1A1TSHRFDPSGGPS1 | |
| SCHEMBL22951461 | 0.79 | DNM1 (0.44) | DNM1TSHRFDPSGGPS1 | |
| SCHEMBL22420015 | 0.79 | DNM1 (0.50) | DNM1ALDH1A1TSHRFDPSGGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884043-B2 | RORgammaT inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-02-06 | — | — | US | disclosed |
| US-20170340610-A1 | RORgammaT INHIBITORS | MERCK SHARP & DOHME LLC | 2017-11-30 | — | — | US | disclosed |
| US-9603838-B2 | RORgammaT inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340610-A1 | RORgammaT INHIBITORS | RORB, RORC, RORA | DNM1 3690/4885LMNA 4532/4885ALDH1A1 858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.