SCHEMBL1867752

SCHEMBL1867752

O=C(O)c1cc2c(cn1)ncn2Cc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 3/20 0.55
CYP11B2 P19099 3/20 0.55
TNF P01375 1/20 0.55
GAA P10253 1/20 0.50
PKM P14618 1/20 0.50
TSHR P16473 1/20 0.50
MMP13 P45452 1/20 0.50
HDAC1 Q13547 2/20 0.48
HDAC8 Q9BY41 1/20 0.48
ALDH1A1 P00352 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
NR1I2 O75469 4/20 0.46
EGLN3 Q9H6Z9 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
FLT3 P36888 1/20 0.45
KDM4C Q9H3R0 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2949310 0.88 MMP13 (0.53) MMP13HDAC1ALDH1A1SMN1; SMN2FLT3
SCHEMBL1869252 0.86 ALDH1A1 (0.49) CYP11B1CYP11B2TNFMMP13HDAC1
SCHEMBL10184009 0.80 HDAC1 (0.41) GAAPKMTSHRHDAC1HDAC8
SCHEMBL1608848 0.79 CYP11B1 (0.60) CYP11B1CYP11B2TNFGAAPKM
SCHEMBL22533766 0.78 SMN1; SMN2 (0.41) CYP11B1CYP11B2TNFMMP13HDAC1
SCHEMBL29424706 0.78 SMN1; SMN2 (0.41) CYP11B1CYP11B2TNFMMP13HDAC1
SCHEMBL2945228 0.77 MMP13 (0.51) CYP11B1CYP11B2TNFMMP13HDAC1
SCHEMBL2943246 0.76 MMP13 (0.50) CYP11B1CYP11B2MMP13HDAC1ALDH1A1
SCHEMBL22533799 0.74 HDAC6 (0.41) MMP13HDAC1ALDH1A1SMN1; SMN2HDAC6
SCHEMBL29424730 0.74 HDAC6 (0.41) MMP13HDAC1ALDH1A1SMN1; SMN2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2493871-A1 NOVEL OXIME DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS Domain Therapeutics (FR) 2012-09-05 EP disclosed
WO-2011051478-A1 NOVEL OXIME DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS DOMAIN THERAPEUTICS (FR) 2011-05-05 WO disclosed