Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN7A | Q01118 | 6/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.57 |
| ▸ | SCN9A | Q15858 | 15/20 | 0.56 |
| ▸ | SCN1A | P35498 | 1/20 | 0.55 |
| ▸ | SCN4A | P35499 | 1/20 | 0.55 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.55 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.55 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17062225 | 0.95 | SCN9A (0.58) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL18662293 | 0.93 | SCN7A (0.62) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| Trifluoroacetic Acid SCHEMBL16759039 | 0.91 | SCN9A (0.56) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL18675676 | 0.90 | SCN9A (0.56) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL17061879 | 0.90 | SCN9A (0.59) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| Trifluoroacetic Acid SCHEMBL28078857 | 0.89 | SCN7A (0.58) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL17062087 | 0.88 | SCN7A (0.60) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| Trifluoroacetic Acid SCHEMBL28338315 | 0.87 | SCN9A (0.56) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL16759258 | 0.87 | SCN9A (0.61) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL17062112 | 0.86 | SCN9A (0.61) | SCN7ASCN5ASCN9ASCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9694002-B2 | Substituted benzamides and methods of use thereof | GENENTECH, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20170087136-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170087136-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | C1R, SRR, PNISR | SCN7A 258/4885SCN5A 631/4885SCN9A 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.