Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 10/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 10/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid Methyl Ester SCHEMBL28797097 | 0.92 | VEGFA (0.52) | VEGFAEGLN1CHRM3PDE1CKMT2A | |
| Tert-Butyl Formate SCHEMBL27882877 | 0.90 | VEGFA (0.49) | VEGFAEGLN1CHRM3PDE1CMAPK14 | |
| Ethoxycarbonyl Group SCHEMBL27866624 | 0.90 | VEGFA (0.49) | VEGFAEGLN1CHRM3PDE1CMAPK14 | |
| SCHEMBL17028831 | 0.87 | VEGFA (0.60) | VEGFAEGLN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1870702 | 0.87 | EGLN1 (0.63) | VEGFAEGLN1CHRM3SMN1; SMN2POLB | |
| SCHEMBL1868340 | 0.87 | VEGFA (0.63) | VEGFAEGLN1ALDH1A1SMN1; SMN2PDE1C | |
| SCHEMBL1866840 | 0.87 | VEGFA (0.63) | VEGFAEGLN1ALDH1A1SMN1; SMN2PDE1C | |
| SCHEMBL1865127 | 0.86 | VEGFA (0.62) | VEGFAEGLN1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL1770508 | 0.85 | VEGFA (0.64) | VEGFAEGLN1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL28797095 | 0.83 | CHRM3 (0.44) | VEGFAEGLN1CHRM3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496236-A1 | PROLYL HYDROXYLASE INHIBITORS | Aerpio Therapeutics Inc. (US) | 2012-09-12 | — | — | EP | claimed |
| WO-2011057115-A1 | PROLYL HYDROXYLASE INHIBITORS | AKEBIA THERAPEUTICS INC. (US) | 2011-05-12 | — | — | WO | claimed |