Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | FES | P07332 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868561 | 1.00 | BRAF (0.43) | BRAFFLT3JAK2MAP4K4CHEK2 | |
| SCHEMBL1867173 | 0.91 | BRAF (0.42) | BRAFFLT3JAK2MAP4K4CHEK2 | |
| SCHEMBL1867170 | 0.91 | BRAF (0.42) | BRAFFLT3JAK2MAP4K4CHEK2 | |
| SCHEMBL1861630 | 0.91 | BRAF (0.45) | BRAFFLT3MASP2KLKB1 | |
| SCHEMBL1861627 | 0.91 | BRAF (0.45) | BRAFFLT3MASP2KLKB1 | |
| SCHEMBL1867508 | 0.90 | BRAF (0.46) | BRAFFLT3JAK2MAP4K4CHEK2 | |
| SCHEMBL1867506 | 0.90 | BRAF (0.46) | BRAFFLT3JAK2MAP4K4CHEK2 | |
| SCHEMBL1873310 | 0.89 | BRAF (0.47) | BRAFFLT3MASP2KLKB1 | |
| SCHEMBL1867774 | 0.89 | BRAF (0.47) | BRAFFLT3MASP2KLKB1 | |
| SCHEMBL1863379 | 0.87 | BRAF (0.47) | BRAFFLT3MAP4K4FESFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051672-A1 | AZAINDOLE DERIVATIVES | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051672-A1 | AZAINDOLE DERIVATIVES | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |