Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 10/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18686155 | 0.94 | CSNK2A1 (0.43) | CSNK2A1PRKCQEGFRERBB2PRKCH | |
| SCHEMBL2124161 | 0.90 | PRKCQ (0.46) | CSNK2A1PRKCQROCK2EGFRERBB2 | |
| SCHEMBL18686159 | 0.88 | CSNK2A1 (0.42) | CSNK2A1PRKCQEGFRERBB2PRKCH | |
| SCHEMBL18686156 | 0.88 | MPO (0.39) | CSNK2A1PRKCQROCK2IDO1TDO2 | |
| SCHEMBL2125445 | 0.86 | PRKCQ (0.38) | CSNK2A1PRKCQROCK2IDO1TDO2 | |
| SCHEMBL2124351 | 0.85 | PRKCQ (0.39) | CSNK2A1PRKCQROCK2EGFRERBB2 | |
| SCHEMBL2126773 | 0.85 | PRKCQ (0.39) | CSNK2A1PRKCQROCK2EGFRERBB2 | |
| SCHEMBL2122787 | 0.85 | PRKCQ (0.38) | CSNK2A1PRKCQROCK2EGFRERBB2 | |
| SCHEMBL2125701 | 0.84 | CSNK2A1 (0.44) | CSNK2A1PRKCQEGFRERBB2PRKCH | |
| SCHEMBL2122015 | 0.84 | CSNK2A1 (0.40) | CSNK2A1PRKCQROCK2EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443123-B1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | RIGEL PHARMACEUTICALS INC (US) | 2017-04-05 | — | — | EP | claimed |