Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18686168 | 0.94 | CSNK2A1 (0.43) | MPOCSNK2A1PRKCQADORA2BADORA2A | |
| SCHEMBL2125445 | 0.94 | PRKCQ (0.38) | CSNK2A1PRKCQIDO1TDO2ADORA2B | |
| SCHEMBL2124351 | 0.93 | PRKCQ (0.39) | CSNK2A1PRKCQADORA2BGRIN1GRIN2B | |
| SCHEMBL2122787 | 0.91 | PRKCQ (0.38) | CSNK2A1PRKCQGRIN1GRIN2BROCK2 | |
| SCHEMBL2126773 | 0.90 | PRKCQ (0.39) | CSNK2A1PRKCQGRIN1GRIN2BROCK2 | |
| SCHEMBL2124161 | 0.90 | PRKCQ (0.46) | CSNK2A1PRKCQROCK2EGFRERBB2 | |
| SCHEMBL2123468 | 0.88 | PRKCQ (0.42) | CSNK2A1PRKCQGRIN1GRIN2BROCK2 | |
| SCHEMBL2125521 | 0.88 | PRKCQ (0.42) | CSNK2A1PRKCQADORA2BADORA2AEGFR | |
| SCHEMBL2125564 | 0.88 | PRKCQ (0.42) | CSNK2A1PRKCQADORA2BADORA2AEGFR | |
| SCHEMBL18686154 | 0.88 | CSNK2A1 (0.39) | CSNK2A1PRKCQIDO1TDO2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443123-B1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | RIGEL PHARMACEUTICALS INC (US) | 2017-04-05 | — | — | EP | claimed |