Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 4/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2123211 | 0.94 | TP53 (0.38) | MAPTSMN1; SMN2PTK2CSNK2A1FYN | |
| SCHEMBL18686160 | 0.90 | F11 (0.38) | NEK2CSNK2A1FYNMAOBF11 | |
| SCHEMBL2124001 | 0.88 | CSNK2A1 (0.43) | CSNK2A1 | |
| SCHEMBL2122928 | 0.86 | CSNK2A1 (0.37) | CSNK2A1FYN | |
| SCHEMBL18686166 | 0.86 | CSNK2A1 (0.45) | MAPTSMN1; SMN2PTK2CSNK2A1MET | |
| SCHEMBL2124785 | 0.85 | BRAF (0.46) | MAPTCSNK2A1FYNMETKDR | |
| SCHEMBL2126704 | 0.83 | KDM4E (0.38) | SMN1; SMN2CSNK2A1METKDRPOLB | |
| SCHEMBL2125785 | 0.83 | EGFR (0.43) | PTK2CSNK2A1 | |
| SCHEMBL2124547 | 0.83 | MAPT (0.42) | MAPTSMN1; SMN2PTK2CSNK2A1POLB | |
| SCHEMBL2123791 | 0.83 | MAPT (0.43) | GAAMAPTSMN1; SMN2POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443123-B1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | RIGEL PHARMACEUTICALS INC (US) | 2017-04-05 | — | — | EP | claimed |