Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18686158 | 0.95 | CSNK2A1 (0.42) | CSNK2A1EGFRERBB2GSK3BCDC25B | |
| SCHEMBL2124547 | 0.93 | MAPT (0.42) | CSNK2A1EGFRERBB2PTK2ALDH1A1 | |
| SCHEMBL18686178 | 0.92 | CSNK2A1 (0.44) | CSNK2A1EGFRERBB2GSK3BCDC25B | |
| SCHEMBL2123140 | 0.89 | MAPT (0.40) | CSNK2A1EGFRERBB2PTK2ALDH1A1 | |
| SCHEMBL2127338 | 0.88 | EGFR (0.49) | CSNK2A1EGFRERBB2ALDH1A1 | |
| SCHEMBL15266840 | 0.87 | CSNK2A1 (0.40) | CSNK2A1EGFRERBB2GSK3BCDC25B | |
| SCHEMBL2125931 | 0.87 | CDK1 (0.43) | CSNK2A1ALDH1A1MAPTSLKKDR | |
| SCHEMBL18686163 | 0.86 | NPC1 (0.37) | CSNK2A1PTK2MAPTSMN1; SMN2MET | |
| SCHEMBL2124067 | 0.85 | MAPT (0.44) | CSNK2A1EGFRERBB2ALDH1A1MAPT | |
| SCHEMBL2124727 | 0.84 | SRC (0.44) | CSNK2A1EGFRPTK2ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443123-B1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | RIGEL PHARMACEUTICALS INC (US) | 2017-04-05 | — | — | EP | claimed |