Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GPR39 | O43194 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15637052 | 0.91 | DRD4 (0.50) | DRD4SIGMAR1KDM1AKDM4EKDM5A | |
| SCHEMBL15637048 | 0.91 | DRD4 (0.50) | DRD4SIGMAR1KDM1AKDM4EKDM5A | |
| SCHEMBL18686364 | 0.79 | DRD4 (0.48) | DRD4SIGMAR1KDM1AKDM4ECXCR3 | |
| SCHEMBL15636850 | 0.79 | DRD4 (0.55) | DRD4SIGMAR1KDM1AKDM5AKDM5C | |
| SCHEMBL15636721 | 0.78 | SIGMAR1 (0.52) | DRD4SIGMAR1KDM4EKDM5CKDM5B | |
| SCHEMBL19676421 | 0.78 | KDM5B (0.45) | DRD4KDM1AKDM5AKDM5CKDM5B | |
| SCHEMBL28249910 | 0.72 | BACE1 (0.51) | SIGMAR1 | |
| SCHEMBL16291580 | 0.72 | CCR3 (0.55) | — | |
| SCHEMBL27542831 | 0.71 | KDM4C (0.63) | KDM4EKDM5AKDM5CKDM5B | |
| SCHEMBL27540032 | 0.70 | DRD4 (0.57) | DRD4SIGMAR1CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |