Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | LMNA | P02545 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18687096 | 1.00 | MEN1 (0.55) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL18687080 | 0.84 | SMN1; SMN2 (0.53) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL18709385 | 0.84 | SMN1; SMN2 (0.53) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL18709525 | 0.83 | LMNA (0.41) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL18687091 | 0.83 | LMNA (0.41) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL20296938 | 0.82 | MAPT (0.43) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL18709333 | 0.82 | MAPT (0.43) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL17329183 | 0.82 | PRMT1 (0.52) | MEN1KMT2ALMNAALDH1A1NPSR1 | |
| SCHEMBL17329184 | 0.82 | PRMT1 (0.52) | MEN1KMT2ALMNAALDH1A1NPSR1 | |
| SCHEMBL18709330 | 0.82 | ALDH1A1 (0.54) | MEN1KMT2AMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10071994-B2 | N-sulfonyl homoserine lactone derivatives, preparation method and use thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-09-11 | — | — | US | claimed |
| US-20180179193-A1 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-06-28 | — | — | US | claimed |
| EP-3150594-A1 | N-SULFONYL HOMOSERINE LACTONE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2017-04-05 | — | — | EP | claimed |
| US-10071994-B2 | N-sulfonyl homoserine lactone derivatives, preparation method and use thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-09-11 | — | — | US | disclosed |
| US-20180179193-A1 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-06-28 | — | — | US | disclosed |
| US-20180179193-A1 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-06-28 | — | — | US | disclosed |
| EP-3150594-A1 | N-SULFONYL HOMOSERINE LACTONE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2017-04-05 | — | — | EP | disclosed |
| EP-3150594-A1 | N-SULFONYL HOMOSERINE LACTONE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2017-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179193-A1 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | LSS, SOS1, STS | MEN1 346/4885KMT2A 3793/4885MAPT 4807/4885 |
| US-10071994-B2 | N-sulfonyl homoserine lactone derivatives, preparation method and use thereof | LSS, SOS1, STS | MEN1 432/4885KMT2A 3890/4885MAPT 4813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.