Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 13/20 | 0.76 |
| ▸ | EPAS1 | Q99814 | 12/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21005016 | 1.00 | VEGFA (0.76) | VEGFAEPAS1 | |
| SCHEMBL21005015 | 0.90 | EPAS1 (0.72) | VEGFAEPAS1 | |
| SCHEMBL21005508 | 0.89 | EPAS1 (0.71) | VEGFAEPAS1 | |
| SCHEMBL21005094 | 0.88 | EPAS1 (0.69) | VEGFAEPAS1 | |
| SCHEMBL16560985 | 0.86 | EPAS1 (1.00) | VEGFAEPAS1 | |
| SCHEMBL21005434 | 0.86 | EPAS1 (1.00) | VEGFAEPAS1 | |
| SCHEMBL21005013 | 0.86 | VEGFA (0.68) | VEGFAEPAS1 | |
| SCHEMBL21005012 | 0.85 | VEGFA (0.75) | VEGFAEPAS1 | |
| SCHEMBL21005370 | 0.85 | VEGFA (0.75) | VEGFAEPAS1 | |
| SCHEMBL30933976 | 0.85 | VEGFA (0.75) | VEGFAEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017053192-A1 | BIOMARKERS OF RESPONSE TO HIF-2-ALPHA INHIBITION IN CANCER AND METHODS FOR THE USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-03-30 | — | — | WO | disclosed |