Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 11/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.57 |
| ▸ | CDK4 | P11802 | 2/20 | 0.57 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | STK25 | O00506 | 1/20 | 0.57 |
| ▸ | CIT | O14578 | 1/20 | 0.57 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.57 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.57 |
| ▸ | CHUK | O15111 | 1/20 | 0.57 |
| ▸ | MUSK | O15146 | 1/20 | 0.57 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22130477 | 0.84 | MAPT (0.55) | KDRCHEK1FGFR1CDK4BMPR1B | |
| SCHEMBL1597265 | 0.82 | KDR (0.65) | KDRCHEK1FGFR1CDK4BMPR1B | |
| SCHEMBL1597267 | 0.82 | KDR (0.65) | KDRCHEK1FGFR1CDK4BMPR1B | |
| SCHEMBL18844727 | 0.81 | CHEK1 (0.53) | KDRCHEK1FGFR1CDK4BMPR1B | |
| SCHEMBL27691457 | 0.81 | CHEK1 (0.53) | KDRCHEK1FGFR1CDK4BMPR1B | |
| SCHEMBL2458766 | 0.80 | CHEK1 (0.67) | KDRCHEK1FGFR1CDK4BMPR1B | |
| SCHEMBL2458765 | 0.80 | CHEK1 (0.67) | KDRCHEK1FGFR1CDK4BMPR1B | |
| SCHEMBL1596784 | 0.80 | KDR (0.60) | KDRCHEK1FGFR1CDK4BMPR1B | |
| SCHEMBL1597445 | 0.80 | KDR (0.60) | KDRCHEK1FGFR1CDK4BMPR1B | |
| SCHEMBL1596786 | 0.80 | KDR (0.60) | KDRCHEK1FGFR1CDK4BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017053638-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF OCULAR DISORDERS | Graybug Vision, Inc. (US) | 2017-03-30 | — | — | WO | disclosed |