Sugi Predict

Sugi Predict / Compounds / SCHEMBL2458765

SCHEMBL2458765

SCHEMBL2458765

C(=C/c1n[nH]c2ccccc12)\c1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CHEK1 O14757 17/20 0.67
▸ KDR P35968 11/20 0.61
▸ FGFR1 P11362 2/20 0.61
▸ CDK4 P11802 3/20 0.60
▸ CCND1 P24385 2/20 0.60
▸ CCND3 P30281 2/20 0.60
▸ CDK1 P06493 1/20 0.60
▸ CCNA2 P20248 1/20 0.60
▸ CDK2 P24941 1/20 0.60
▸ LCK P06239 2/20 0.54
▸ BMPR1B O00238 1/20 0.54
▸ PLK4 O00444 1/20 0.54
▸ STK25 O00506 1/20 0.54
▸ CIT O14578 1/20 0.54
▸ RIOK3 O14730 1/20 0.54
▸ IKBKB O14920 1/20 0.54
▸ AURKA O14965 1/20 0.54
▸ GAK O14976 1/20 0.54
▸ DCLK1 O15075 1/20 0.54
▸ CHUK O15111 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2458766 1.00 CHEK1 (0.67) CHEK1KDRFGFR1CDK4CCND1
SCHEMBL30633894 0.88 CHEK1 (0.63) CHEK1KDRFGFR1CDK4CCND1
SCHEMBL5693185 0.86 CHEK1 (0.56) CHEK1KDRFGFR1CDK4CCND1
SCHEMBL22130477 0.86 MAPT (0.55) CHEK1KDRFGFR1CDK4CCND1
SCHEMBL18813990 0.86 CHEK1 (0.53) CHEK1KDRFGFR1CDK4CCND1
SCHEMBL18844727 0.86 CHEK1 (0.53) CHEK1KDRFGFR1CDK4CCND1
SCHEMBL5693180 0.86 CHEK1 (0.56) CHEK1KDRFGFR1CDK4CCND1
Hydrochloric Acid SCHEMBL5693182 0.85 KDR (0.52) CHEK1KDRFGFR1CDK4CCND1
Hydrochloric Acid SCHEMBL5693177 0.85 KDR (0.52) CHEK1KDRFGFR1CDK4CCND1
SCHEMBL1597265 0.85 KDR (0.65) CHEK1KDRFGFR1CDK4LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115947690-B Preparation method of indazole molecular building block and application of indazole molecular building block in drug synthesis 安徽医科大学 2025-04-08 — — CN disclosed
CN-115947690-A Preparation method of indazole molecular building block and application of building block in drug synthesis 安徽医科大学 2023-04-11 — — CN disclosed
US-20150313881-A1 Therapeutic Methods for Type I Diabetes UNIVERSITY OF MASSACHUSETTS 2015-11-05 — — US disclosed
US-8501812-B2 Therapeutic methods for type I diabetes UNIVERSITY OF MASSACHUSETTS (US) 2013-08-06 — — US disclosed
EP-1847532-B1 IGF-1R INHIBITOR KYOWA HAKKO KIRIN CO LTD (JP) 2013-06-05 — — EP disclosed
US-20120329794-A1 Ab1 KINASE INHIBITORS KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-12-27 — — US disclosed
US-20120208846-A1 Therapeutic Methods For Type I Diabetes UNIVERSITY OF MASSACHUSETTS 2012-08-16 — — US disclosed
US-20110237633-A1 SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2011-09-29 — — US disclosed
US-7919517-B2 Indazole derivatives KYOWA HAKKO KIRIN CO., LTD. (JP) 2011-04-05 — — US disclosed
US-7897572-B1 Theraputic methods for type I diabetes UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL (US) 2011-03-01 — — US disclosed
US-20090209537-A1 AURORA INHIBITORS KYOWA HAKKO KIRIN CO., LTD. (JP) 2009-08-20 — — US disclosed
US-20090082348-A1 INDAZOLE DERIVATIVES KYOWA HAKKO KOGYO CO., LTD. (JP) 2009-03-26 — — US disclosed
US-20090054508-A1 IGF-1R INHIBITOR KYOWA HAKKO KOGYO CO., LTD. (JP) 2009-02-26 — — US disclosed
US-20090054508-A1 IGF-1R INHIBITOR KYOWA HAKKO KOGYO CO., LTD. (JP) 2009-02-26 — — US disclosed
US-7470717-B2 Indazole derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 2008-12-30 — — US disclosed
EP-1847532-A1 IGF-1R INHIBITOR KYOWA HAKKO KOGYO CO., LTD. (JP) 2007-10-24 — — EP disclosed
WO-2007076161-A2 COMPOUNDS WITH THERAPEUTIC ACTIVITY MYRIAD GENETICS, INC (US) 2007-07-05 — — WO disclosed
US-20070117856-A1 Indazole derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 2007-05-24 — — US disclosed
US-20060281789-A1 Protein kinase inhibitors KYOWA HAKKO KOGYO CO., LTD (JP) 2006-12-14 — — US disclosed
EP-1650194-A1 PROTEIN KINASE INHIBITOR KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-04-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110237633-A1 SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, MET CHEK1 2771/4885KDR 80/4885FGFR1 11/4885
US-20060281789-A1 Protein kinase inhibitors MAP3K20, MAP3K1, MAP3K19 CHEK1 247/4885KDR 1545/4885FGFR1 575/4885
US-20120329794-A1 Ab1 KINASE INHIBITORS ABL2, ABL1, MAPK1 CHEK1 739/4885KDR 702/4885FGFR1 111/4885
US-20150313881-A1 Therapeutic Methods for Type I Diabetes MAPK9, IAPP, RNASE1 CHEK1 3913/4885KDR 3572/4885FGFR1 1017/4885
US-20120208846-A1 Therapeutic Methods For Type I Diabetes MAPK9, IAPP, RNASE1 CHEK1 3913/4885KDR 3572/4885FGFR1 1017/4885
US-20070117856-A1 Indazole derivatives IGF1R, NR0B2, ADRA2B CHEK1 2191/4885KDR 383/4885FGFR1 261/4885
US-20090082348-A1 INDAZOLE DERIVATIVES IGF1R, NR0B2, ADRA2B CHEK1 2191/4885KDR 383/4885FGFR1 261/4885
US-20090054508-A1 IGF-1R INHIBITOR IGF1R, IGFBP5, IGFBP1 CHEK1 3274/4885KDR 75/4885FGFR1 18/4885
US-20090209537-A1 AURORA INHIBITORS AURKA, AURKB, AURKC CHEK1 37/4885KDR 1213/4885FGFR1 374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.