Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.57 |
| ▸ | CYP17A1 | P05093 | 7/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1864534 | 0.76 | PRKCA (0.78) | PRKCACYP17A1CYP19A1MEN1KMT2A | |
| SCHEMBL14488494 | 0.73 | CYP17A1 (0.50) | PRKCACYP17A1CYP19A1MEN1KMT2A | |
| SCHEMBL16731832 | 0.72 | CYP17A1 (0.55) | PRKCACYP17A1CYP19A1MEN1KMT2A | |
| SCHEMBL19475250 | 0.71 | CYP17A1 (0.54) | PRKCACYP17A1CYP19A1MEN1KMT2A | |
| SCHEMBL2754983 | 0.70 | PRKCA (0.51) | PRKCACYP17A1CYP19A1MEN1KMT2A | |
| SCHEMBL10531426 | 0.70 | PRKCA (0.51) | PRKCACYP17A1CYP19A1MEN1KMT2A | |
| SCHEMBL16731843 | 0.70 | PRKCA (0.51) | PRKCACYP17A1CYP19A1MEN1KMT2A | |
| SCHEMBL13447507 | 0.70 | PRKCA (0.61) | PRKCACYP17A1CYP19A1MEN1KMT2A | |
| SCHEMBL16941753 | 0.70 | PRKCA (0.54) | PRKCACYP17A1CYP19A1MEN1KMT2A | |
| SCHEMBL26011236 | 0.70 | PRKCA (0.48) | PRKCACYP17A1CYP19A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1935879-B1 | SUBSTITUTED CYCLOALKENE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2016-05-11 | — | — | EP | disclosed |
| US-RE43858-E1 | Substituted cycloalkene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-12-11 | — | — | US | disclosed |
| US-7935835-B2 | Substituted cycloalkene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-05-03 | — | — | US | disclosed |
| US-20090233952-A1 | SUBSTITUTED CYCLOALKENE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-09-17 | — | — | US | disclosed |
| EP-1935879-A1 | SUBSTITUTED CYCLOALKENE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2008-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233952-A1 | SUBSTITUTED CYCLOALKENE DERIVATIVE | CD40, LITAF, TNF | PRKCA 703/4885CYP17A1 1456/4885CYP19A1 2524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.