Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | PTGES | O14684 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.54 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2515756 | 0.96 | MAPT (0.60) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL3498303 | 0.86 | MAPT (0.54) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL2301247 | 0.82 | SIRT2 (0.61) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL16745591 | 0.82 | HSD17B10 (0.67) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL10099057 | 0.82 | MAPT (0.57) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL20780028 | 0.81 | MAPT (0.56) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL3238110 | 0.80 | L3MBTL1 (0.78) | LMNAKDM4EL3MBTL1ACHEGRIN1 | |
| SCHEMBL26836971 | 0.80 | KMT2A (0.55) | LMNAKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10127681 | 0.80 | L3MBTL1 (0.82) | LMNAKDM4EALDH1A1L3MBTL1ACHE | |
| SCHEMBL6643889 | 0.79 | ALDH1A1 (0.68) | MAPTLMNAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486990-B2 | SirT inhibitors that bind to NAD | ELIXIR PHARMACEUTICALS, INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110104177-A1 | HISTONE DEACETYLASE INHIBITORS, COMBINATION THERAPIES AND METHODS OF USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110104177-A1 | HISTONE DEACETYLASE INHIBITORS, COMBINATION THERAPIES AND METHODS OF USE | HDAC1, HDAC5, HDAC4 | MAPT 3378/4885LMNA 2192/4885KDM4E 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.