Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18691758 | 0.88 | HDAC6 (0.42) | ATMMAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL18691790 | 0.87 | ATM (0.49) | ATMMAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL18691774 | 0.81 | ELANE (0.47) | ATMMAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL29724622 | 0.80 | ALDH1A1 (0.59) | MAPTTP53SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL2783065 | 0.80 | ALDH1A1 (0.59) | MAPTTP53SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL18691783 | 0.78 | ATM (0.55) | ATMMAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL18691789 | 0.75 | TP53 (0.39) | ATMMAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL15147600 | 0.71 | MEN1 (0.45) | MAPTTP53SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL9611673 | 0.70 | ATM (1.00) | ATMMAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL18691788 | 0.70 | KMT2A (0.44) | MAPTTP53ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247292-B1 | PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2017-04-12 | — | — | EP | disclosed |