Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18691775 | 0.90 | ELANE (0.45) | ELANEKDM4EALDH1A1HSD17B10ADORA3 | |
| SCHEMBL2783058 | 0.83 | OGFRL1 (0.56) | KDM4EALDH1A1NPC1TP53MAPT | |
| SCHEMBL18691762 | 0.81 | ATM (0.54) | ATMKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL18691790 | 0.80 | ATM (0.49) | ATMKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3346273 | 0.76 | MAPT (0.49) | ELANEATMALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL15147594 | 0.76 | TARBP2 (0.48) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL18691786 | 0.74 | LMNA (0.60) | KDM4EALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL18691772 | 0.74 | ADORA3 (0.49) | ELANEKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL18691783 | 0.74 | ATM (0.55) | ATMKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL15147620 | 0.72 | OGFRL1 (0.44) | ELANEKDM4EALDH1A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247292-B1 | PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2017-04-12 | — | — | EP | disclosed |